Thursday, February 28, 2013

Antarctic scientists discover 18-kilogram meteorite

Feb. 28, 2013 ? An international team of scientists, working at Princess Elisabeth Antarctica research station, have discovered a meteorite with a mass of 18 kilograms embedded in the East Antarctic ice sheet, the largest such meteorite found in the region since 1988.

The eight members of the SAMBA project, from Universit? Libre de Bruxelles (ULB) and Vrije Universiteit Brussel (VUB), Japan's National Institute of Polar Research (NIPR) and Tokyo University were searching for meteorites scattered across the Nansen Ice Field on January 28, when they found the 18kg ordinary chondrite. The team discovered a total of 425 meteorites, with a total weight of 75kg during the 40 day expedition, at an altitude of 2,900m, 140km south of Belgium's Princess Elisabeth Antarctica research base.

"This meteorite was a very unexpected find for us, not only due to its weight, but because we don't normally find such large meteorites in Antarctica," said Vinciane Debaille, a geologist from Universit? Libre de Bruxelles, who led the Belgian part of the team during the expedition. "This is the biggest meteorite found in East Antarctica for 25 years, so it's a very special discovery for us, only made possible by the existence and location of Princess Elisabeth Antarctica."

The SAMBA project contributes to the US and Japan-led global collection of Antarctic meteorites, and is an initiative of VUB and ULB, in collaboration with the Japanese Institute of Polar Research. SAMBA is supported by the Belgian Science Policy (BELSPO) and the International Polar Foundation.

Initial field analysis by the scientists suggests that the 18kg meteorite is an ordinary chondrite, the most abundant kind of meteorite. The fusion crust -- the meteorite's outer casing -- was eroded, allowing the scientists to inspect the rock underneath. The meteorite is currently undergoing a special thawing process in Japan -- to ensure water doesn't get inside the rock.

"We study meteorites in order to better understand how the solar system formed, how it evolved, how the Earth became such a unique planet in our solar system," said Debaille. "This season's SAMBA mission was a success both in terms of the number and weight of the meteorites we found. Two years ago, we found less than 10kg. This year, we found so much that we had to call the travel agency -- because we had 75kg of meteorites to take home."

Princess Elisabeth Antarctica is the world's first zero emission polar research station, and is operated by the International Polar Foundation, in partnership with the Belgian Polar Secretariat. Princess Elisabeth Antarctica's design and construction seamlessly integrates passive building technologies, renewable wind and solar energy, water treatment facilities, continuously monitored power demand and a smart grid for maximising energy efficiency. Located in East Antarctica's S?r Rondane Mountains, Princess Elisabeth Antarctica welcomes scientists from around the world to conduct research in this little-studied and pristine environment.

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The above story is reprinted from materials provided by International Polar Foundation.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/mEIfzPgiWtw/130228113401.htm

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Wednesday, February 27, 2013

Noomi Rapace Says Prometheus 2 Script Is in the Works

prometheus-movie-image-green-rapace-fassbender-slice

While I was ultimately disappointed with Ridley Scott?s Prometheus, it certainly did conjure up an awful lot of discussion and interest in Scott?s planned sequel. ?Star Noomi Rapace recently spoke with the director about the second film and revealed that work on the script is still underway. ?We don?t know who the writer is at the moment, but we do know that Damon Lindelof won?t return to the franchise. ?Hit the jump to see what Rapace ?did?manage to talk about.

noomi-rapace-prometheusIn a recent interview with The Playlist for her upcoming film Dead Man Down, Rapace gave a brief update on the status of the?Prometheus?sequel, saying:

?They?re working on the script. I met Ridley in London a couple of weeks ago. I would love to work with him again and I know that he would like to do another one. It?s just like we need to find the right story. I hope we will.?

Whatever the story ends up being, it sounds like Rapace had enough fun on the first experience that she?d love the opportunity to do it again:

?I love working with Ridley. It was pure joy. It was really hard work sometimes. My body was a complete mess ? I had bruises and cuts and emotionally I was a bit slammed. But being in his world and his universe was such an amazing experience.?

Though Rapace didn?t know (or played innocent) about the identity of the screenwriters attached to the sequel, she did comment on the reactions to the original film:

?And it?s interesting because people, most people I?ve talked to who see the movie, see things that are quite different. Some people who see the movie many times and discover new things. There are all these religious aspects and there are very interesting conversations. And for me, if we do a second one, there are a lot of things to explore in there and to continue. I would love to do it.?

The?Prometheus?sequel is currently targeted for a 2014 or, more likely, 2015 release date, with both Rapace and Michael Fassbender contractually obligated to return if and when it moves forward.

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Source: http://www.rottentomatoes.com/m/1926927/news/1926927/

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The Surprising Truth About Baby Boomer Health | Care2 Healthy ...

From Woodstock, to women?s rights, Baby boomers have made a name for themselves by being unpredictable, off-beat pioneers; rejecting society?s norms and labels.

But this time, the label they?re rejecting?that of the ?healthiest generation??may, in the long run, do them more harm than good.

In spite of having access to groundbreaking medical advancements and record amounts of wealth, the baby boom generation is sicker and more impaired than their parents were at the same age, according to a new article published in the Journal of the American Medical Association.

Baby boomer life expectancy does exceed that of previous generations, but their overall health is not better, study authors noted.

And they know it too.

Only 13 percent of baby boomers feel that their overall wellness is, ?excellent,? compared to 32 percent of people in the prior generation who gave their health top marks.

Here are a few specific findings from the report:

The positives: Baby boomers are less likely to smoke or have already had a heart attack than their parents were.

The negatives: Baby boomers are much less likely to exercise on a regular basis?a whopping 52 percent said they get no regular physical activity. Consequently, they are also much more likely to be obese (39 percent of boomers versus 29 percent of the previous generation), have high cholesterol (74 percent versus 34 percent), and suffer from diabetes (16 percent versus 12 percent), than their parents.

When they were their age, about nine percent of baby boomer parents had problems carrying out daily tasks, such as getting around the house and doing chores. Thirteen percent of boomers report currently having similar problems.

Seven percent of boomers have to use a cane (or similar device) to get around, versus three percent of their parents at the same age.

Make an action plan for healthy aging

Aging baby boomers, even those who don?t feel in tip-top shape, shouldn?t view aging as a life-sentence of inevitable decline. There are steps you can take to help yourself age successfully.

?You may not be able to regain the health that you had at age 20 or 30, but you can always improve your physical and mental health,? says Larry Matson, Ed.D., co-author of the book, ?Live Young, Think Young, Be Young?at Any Age.?

He suggests taking small, manageable steps to regain control over the common issues of aging that affect your physical and mental health.

Set a goal to go for a 15 minute walk each day. Replace your daily diet soda with a glass of water, or all-natural juice. Eat a piece of fruit in place of dessert. Pay attention to and manage your stress levels by making an action plan to calm yourself down.

?The power of a different mindset about aging is the key,? Matson says. ?Raise your expectations and take it day by day. We?re all going to die, eventually, but even small changes can result in positive adaptations?no matter how old you are.?

Discover more tips on how to incorporate better health habits into your daily routine:

Baby Boomers Blaze New Trail as ?Unhealthiest? Generation originally appeared on AgingCare.com.

Source: http://www.care2.com/greenliving/the-surprising-truth-about-baby-boomer-health.html

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GlaxoSmithKline unit joins patent pool for AIDS drugs

LONDON (Reuters) - GlaxoSmithKline's HIV/AIDS drugs business is to share intellectual property rights on children's medicine in a patent pool designed to make treatments more widely available in poor countries.

ViiV Healthcare, majority-owned by GSK, is the second research-based pharmaceutical business to sign up to the new Medicines Patent Pool, following a lead set in 2011 by Gilead Sciences.

Although more than half of people living with the human immunodeficiency virus (HIV) that causes AIDS now get the drugs they need - thanks to a major roll-out of treatment in Africa - an estimated 6.8 million still go without, according to UNAIDS.

The Medicines Patent Pool (MPP), launched in 2010 by the UNITAID health financing system that is funded by a levy on airline tickets, aims to address the remaining gap by getting patent holders to share know-how with makers of cheap generic drugs.

In the case of ViiV, a key pediatric medicine known as abacavir will be made available to generic manufacturers which will be able to take a license to make and sell it in 118 poor countries, the patent pool said on Wednesday.

ViiV and the patent pool have also agreed to negotiate further licenses that will allow generics firms to manufacture low-cost versions of an experimental drug, dolutegravir, that is currently awaiting regulatory approval in Western markets.

There are 3.4 million children living with HIV worldwide but only 562,000 have access to medicines. Treating them is challenging because many drugs are not adapted for use in children.

Abacavir and dolutegravir are both seen as priority products for fighting HIV in poor countries. ViiV also sells other older drugs, some of which are already off patent and available as cheaper generics.

ViiV - which is owned 76.5 percent by GSK, 13.5 percent by Pfizer and 10 percent by Shionogi - only signed up to the patent pool after lengthy negotiations.

Some other major drugmakers have yet to join.

Bristol-Myers Squibb, Roche and privately owned Boehringer-Ingelheim are currently discussing plans to join the scheme, but Abbott, Johnson & Johnson and Merck have so far remained outside.

J&J decided in November to take unilateral action by not enforcing its patents on HIV drug Prezista in a limited number of poor countries, in a move that disappointed campaigners who argued joining the pool would have been more effective.

(Reporting by Ben Hirschler, Editing by Kate Kelland and Mark Potter)

Source: http://news.yahoo.com/glaxosmithkline-unit-joins-patent-pool-aids-drugs-143054011--finance.html

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Distinct niches in bone marrow nurture blood stem cells

Monday, February 25, 2013

In research that could one day improve the success of stem cell transplants and chemotherapy, scientists have found that distinct niches exist in bone marrow to nurture different types of blood stem cells.

Stem cells in the blood are the precursors to infection-fighting white blood cells and oxygen-carrying red blood cells.

The research, by a team at Washington University School of Medicine in St. Louis, is reported Feb. 24 in the advance online edition of Nature.

The new findings, in mice, suggest that it may be possible to therapeutically target support cells in a particular niche. On the one hand, a drug that nourishes support cells could encourage blood stem cells to establish themselves in the bone marrow, enabling patients who have had stem cell transplants to more quickly rebuild their immune systems.

On the other, tumor cells are known to hide in the bone marrow, and a drug that disrupts the niche environment may drive cancer cells into the bloodstream, where they are more vulnerable to the damaging effects of chemotherapy.

"Our results offer hope for targeting these niches to treat specific cancers or to improve the success of stem cell transplants," says senior author Daniel Link, MD, the Alan A. and Edith L. Wolff Professor of Medicine. "Already, we and others are leading clinical trials to evaluate whether it is possible to disrupt these niches in patients with leukemia or multiple myeloma."

Working in the mice, the researchers selectively deleted a critical gene, CXCL12, which is known to be important for keeping blood stem cells healthy. Rather than knock out the gene in all of the support cells in a niche, the researchers deleted the gene in specific types of support cells. This led to the discovery that each niche holds only certain blood stem cells that are nourished by a unique set of support cells.

"What we found was rather surprising," Link says. "There's not just one niche for developing blood cells in the bone marrow. There's a distinct niche for stem cells, which have the ability to become any blood cell in the body, and a separate niche for infection-fighting blood cells that are destined to become T cells and B cells."

The findings provide a strong foundation for investigating whether disrupting these niches can improve the effectiveness of chemotherapy.

In a phase II pilot study led by Washington University medical oncologist Geoffrey Uy, MD, assistant professor of medicine, Link is evaluating whether the drug G-CSF can alter the stem cell niche in patients with acute lymphoblastic leukemia whose cancer has recurred or is resistant to treatment. The drug was approved by the Food and Drug Administration more than 20 years ago to stimulate production of white blood cells in patients undergoing chemotherapy, who often have weakened immune systems and are prone to infections.

But Uy and colleagues will evaluate the drug when it is given before chemotherapy. Patients enrolled in the trial at the Siteman Cancer Center will receive G-CSF for five days before chemotherapy, and the investigators will determine whether it can disrupt the protective environment of the bone marrow niche and make cancer cells more sensitive to chemotherapy.

While it's too early to know whether the treatment approach will be successful, Link's new research in mice is bolstered by a companion paper in the same issue of Nature. In that research, Sean Morrison, PhD, director of the Children's Medical Center Research Institute at the University of Texas Southwestern Medical Center in Dallas, used similar molecular methods to also discover distinct niches in the bone marrow for blood stem cells.

"There's a lot of interest right now in trying to understand these niches," Link adds. "Both of these studies add new information that will be important as we move forward. Next, we hope to understand how stem cell niches can be manipulated to help patients undergoing stem cell transplants."

###

Greenbaum A, Hsu Y-MS, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 production by early mesenchymal progenitors is required for haemoatopoietic stem-cell maintenance. Nature. Advance online publication Feb. 24, 2013.

Washington University School of Medicine: http://www.medicine.wustl.edu

Thanks to Washington University School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126999/Distinct_niches_in_bone_marrow_nurture_blood_stem_cells

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Tuesday, February 26, 2013

Fungal cleaning crew: Chemists determine the structure of an enzyme that breaks down dyes

Feb. 26, 2013 ? Fungi serve as a kind of natural cleaning crew for the ecosystem. They form enzymes that can degrade hazardous substances, converting natural as well as human-made toxins into harmless compounds. For instance, they can help to break down synthetic dyes, which accumulate in great amounts during the production of textiles. Prof. Dr. Dietmar A. Plattner, Dr. Klaus Piontek, and Eric Strittmatter from the Institute of Organic Chemistry of the University of Freiburg and their colleagues from research groups at the International Graduate School of Zittau of the University of Dresden have determined the three-dimensional atomic structure of an enzyme of this kind, a dye-decolorizing peroxidase (DyP).

Their findings have now been published in the Journal of Biological Chemistry (JBC).

In nature, all organisms make use of enzymes in order to build up and break down vital substances. These biocatalysts are often superior to traditional chemical processes as they enable chemical reactions under especially mild conditions. Several fungal enzymes are commonly used in industry as a replacement for other chemicals. In clothing production, for example, they are the reagents responsible for giving blue jeans a so-called stonewashed or used look.

Plattner's research team is studying several fungal enzymes and attempting to analyze their structure. The scientists hope that this will lead to a better understanding of how the enzymes function. Up until the end of 2010, the scientists were consortium members of the European Union project BIORENEW that was funded with a total of 15 million. They are now participating in the project BioIndustrie2021, which is receiving 1.1 euros in funding from the Federal Ministry of Education and Research. The Freiburg researchers are currently focusing their efforts on enzymes of the class heme peroxidase.. In the future, they hope to use their findings to design custom-made enzymes for industrial applications, making many chemical processes more environmentally friendly.

The dye-decolorizing peroxidase (DyP) belongs to the class of heme peroxidases and is isolated from jelly ear (Auricularia auricula-judae), an edible fungus indigenous to Germany. Piontek and Strittmatter used x-ray crystallographic methods to elucidate the atomic structure of the enzyme. With the help of this model, they determined how the substrate molecules need to bind to the enzyme in order to be converted to other substances in a chemical reaction. While studying this mechanism, they discovered an apparent contradiction: The binding pocket is only large enough for some of the substrate molecules -- for the smaller chemical compounds that are converted by the enzyme. However, it is too small for larger and bulky substrates such as synthetic dyes. Hence, there must be another binding site on the surface of the enzyme that larger molecules can dock onto.

The members of Plattner's team succeeded in locating this site. In addition, they identified the amino acid that enables the enzyme to interact with the substrate and transfers an electron from the substrate molecule to the center of the enzyme.

This is the second example of a so-called redox-active surface amino acid to be found in fungal enzymes to date.

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The above story is reprinted from materials provided by Albert-Ludwigs-Universit?t Freiburg, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. E. Strittmatter, C. Liers, R. Ullrich, S. Wachter, M. Hofrichter, D. A. Plattner, K. Piontek. First Crystal Structure of a Fungal High-redox Potential Dye-decolorizing Peroxidase: SUBSTRATE INTERACTION SITES AND LONG-RANGE ELECTRON TRANSFER. Journal of Biological Chemistry, 2012; 288 (6): 4095 DOI: 10.1074/jbc.M112.400176

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/OWhLhqYauWY/130226092008.htm

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Internet Explorer 10 for Windows 7 Is Finally Available for Download

Windows 7 users are finally getting Internet Explorer 10. They'll be auto-upgraded in a few weeks, but you can go ahead and download the updated browser starting today. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/MHWkuA1PxM8/internet-explorer-10-for-windows-7-is-finally-available-for-download

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Monday, February 25, 2013

Google Had a Big Ol' Hole In Its Two-Step Verification System

The coast is clear now, but for a while there, Google's two-step verification system wasn't keeping you as safe as you thought. In fact, it was providing an avenue for folks to get in. App-specific passwords were propping your door open. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/9PZivD_Z3ng/google-had-a-big-ol-hole-in-its-two+step-verification-system

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Syria says it's prepared to talk with armed rebels

BEIRUT (AP) ? Syria said Monday it is prepared to hold talks with armed rebels bent on overthrowing President Bashar Assad, the clearest signal yet that the regime is growing increasingly nervous about its long-term prospects to hold onto power as opposition fighters make slow but persistent headway in the civil war.

Meanwhile, the umbrella group for Syrian opposition parties said it had reversed a decision to boycott a conference in Rome being held to help drum up financial and political support for the opposition. Walid al-Bunni, a spokesman for the Syrian National Coalition, said the move came after a phone call between the group's leader, Mouaz al-Khatib, and U.S. Secretary of State John Kerry.

Al-Bunni told pan-Arab broadcaster Al-Arabiya the decision was made based on guarantees al-Khatib heard from western diplomats that the conference would be different this time. He did not elaborate. The boycott had put the group at odds with its Western backers.

The Syrian talks offer, made by Foreign Minister Walid al-Moallem during a visit to Moscow, came hours before residents of Damascus and state-run TV reported a huge explosion and a series of smaller blasts in the capital, followed by heavy gunfire.

State-run news agency SANA said there were multiple casualties from the explosion, which it said was a suicide car bombing. Britain-based activist group the Syrian Observatory for Human Rights said the explosions targeted a checkpoint, adding there were initial reports of at least five regime forces killed and several wounded.

The talks proposal marked the first time that a high-ranking regime official has stated publicly that Damascus would be willing to meet with the armed opposition. But al-Moallem did not spell out whether rebels would first have to lay down their weapons before negotiations could begin ? a crucial sticking point in the past.

The regime's proposal is unlikely to lead to talks. The rebels battling the Syrian military have vowed to stop at nothing less than Assad's downfall and are unlikely to agree to sit down with a leader they accuse of mass atrocities.

But the timing of the proposal suggests the regime is warming to the idea of a settlement as it struggles to hold territory and claw back ground it has lost to the rebels in the nearly 2-year-old conflict.

Opposition fighters have scored several tactical victories in recent weeks, capturing the nation's largest hydroelectric dam and overtaking air bases in the northeast. In Damascus, they have advanced from their strongholds in the suburbs into neighborhoods in the northeast and southern rim of the capital, while peppering the center of the city with mortar rounds for days.

Monday night's explosion struck about 800 yards (meters) from Abbasid Square, a landmark plaza in central Damascus. It was followed by several other smaller blasts thought to be mortar shells landing in various districts of the capital. The blasts and subsequent gunfire caused panic among residents who hid in their apartments.

On Thursday, a car bomb near the ruling Baath Party headquarters in Damascus killed at least 53 people, according to state media.

While the momentum appears to be shifting in the rebels' direction, the regime's grip on Damascus remains firm, and Assad's fall is far from imminent.

Still, Monday's offer to negotiate with the armed opposition ? those whom Assad referred to only in January as "murderous criminals" and refused to talk with ? reflects the regime's realization that in the long run, its chances of keeping its grip on power are slim.

Asked about al-Moallem's remarks, U.S. State Department spokesman Patrick Ventrell said the offer of talks was a positive step "in the context of them raining Scuds down on their own civilians." But he expressed caution about the seriousness of the offer.

"I don't know their motivations, other than to say they continue to rain down horrific attacks on their own people," Ventrell told reporters in Washington. "So that speaks pretty loudly and clearly."

If the Assad regime is serious, he said, it should inform the U.N. peace envoy, Lakhdar Brahimi of its readiness for talks. Ventrell said the regime hasn't done that yet.

Andrew Tabler, a fellow at the Washington Institute, called the offer "a sign of weakness."

"I think everybody knows, including Bashar Assad, that they (the regime) can't hang onto the whole country," Tabler said.

Mustafa Alani, an analyst with the Gulf Research Center in Geneva, said the regime has "reached the conclusion that they are heading toward a major defeat eventually, and this is the right time to negotiate."

"They are not losing miles every day, but they are losing substantial ground every day. So the regime is not genuine (in its offer) because it has changed, it's genuine because it is responding to a major shift in the balance of power on the ground," he added.

Alani cautioned, however, that the regime is also eager to keep the idea of talks alive in order to forestall any Western decision on arming the rebels. As long as the possibility of negotiations is still on the table, the U.S. and the European Union ? which have so far provided only non-lethal aid ? will be reluctant to open the flood gates on weapons for the opposition, he said.

"The whole regime tactic is to delay supplying arms, to buy time," Alani said. "The regime can show good will. Whether they're a viable partner or not is a different story."

It's also unclear who exactly the regime would sit across from at the negotiating table.

The dozens of armed groups across Syria fall under no unified command and do not answer to the Syrian National Council, which the West recognizes as the legitimate representative of the Syrian people.

At least one group offered a lukewarm response Monday to al-Moallem's proposal. Free Syrian Army chief Gen. Salim Idriss, said he is "ready to take part in dialogue within specific frameworks," but then rattled off conditions that the regime has rejected in the past.

"There needs to be a clear decision on the resignation of the head of the criminal gang, Bashar Assad, and for those who participated in the killing of the Syrian people to be put on trial," Idriss told Al-Arabiya TV.

He said the government must agree to stop all kinds of violence and to hand over power, stating that "as rebels, this is our bottom line."

Syria's 23-month-old conflict, which has killed more than 70,000 people and destroyed many of the country's cities, has repeatedly confounded international efforts to bring the parties together to end the bloodshed. Russia, a close ally of Assad and his regime's chief international advocate, offered Feb. 20, in concert with the Arab League, to broker talks between the rebels and the government.

With the proposal, which the Kremlin would be unlikely to float publicly without first securing Damascus' word that it would indeed take part, Moscow ratcheted up the pressure on Syria to talk to the opposition.

Russia has shielded Assad's government from U.N. action and kept shipping weapons to the military, but it is growing increasingly difficult to protect the regime as the violence grinds on.

Russian Foreign Minister Sergey Lavrov repeated his call Monday for Syria to negotiate with the opposition, saying before meeting al-Moallem that "the situation in Syria is at a crossroads now." He also warned that further fighting could lead to "the breakup of the Syrian state."

Past government offers for talks with the opposition have included a host of conditions, such as demanding that the rebels first lay down their arms. Those proposals have been swiftly rejected by both activists outside Syria and rebels on the ground.

Both sides in the conflict in recent weeks have floated offers and counteroffers to hold talks on the crisis.

In a speech in January, Assad offered to lead a national dialogue to end the bloodshed, but said he would not talk with the armed opposition and vowed to keep fighting. The opposition rejected the proposal.

This month, the SNC's al-Khatib said he would be open to discussions with the regime that could pave the way for Assad's departure, but that the government must first release tens of thousands of detainees. The government refused, and even members within the coalition balked at the idea of talks.

Speaking to reporters Monday in Cairo, al-Khatib accused the regime of procrastinating and said it had derailed his dialogue offer by not responding to the coalition's conditions.

"We are always open to initiatives that stop the killing and destruction, but the regime rejected the simplest of humanitarian conditions. We have asked that the regime start by releasing women prisoners and there was no response," he said. "This regime must understand that the Syrian people do not want it anymore."

The U.S.'s Kerry on Monday urged rebel leaders not to skip the Rome meeting and insisted that more help is on the way.

Kerry made a public plea at a joint news conference with British Foreign Secretary William Hague and also called al-Khatib "to encourage him to come to Rome," a senior U.S. official said. The official spoke on condition of anonymity because he wasn't authorized to speak publicly on the matter.

Meanwhile, the fighting inside Syria rages on.

The Observatory reported heavy clashes Monday near a police academy in Khan al-Asal just outside Aleppo.

Rebels backed by captured tanks launched an offensive on the facility Sunday. Observatory director Rami Abdul-Rahman said at least 13 rebels and five regime troops were killed.

In another part of Aleppo, rebels downed a military helicopter near the Mennegh airport, where there have been fierce clashes for months.

A video posted online by activists showed a missile being fired, a trail of white smoke and the aircraft going up in flames. Voices in the background shouted, "God is great!" as a man raised both hands in celebration.

The video appeared to be authentic and corresponded to other AP reporting.

___

Associated Press writers Nataliya Vasilyeva in Moscow, Albert Aji in Damascus, Zeina Karam in Beirut, Matthew Lee in London, Bradley Klapper in Washington and Geir Moulson in Berlin contributed to this report.

Source: http://news.yahoo.com/syria-says-prepared-talk-armed-rebels-195253563.html

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Kerry takes case on Syria to Europe, Mideast

FILE - In this Feb. 14, 2013 file photo, Secretary of State John Kerry speaks at the State Department in Washington. Kerry will make his first overseas trip next week to Europe and the Middle East, but is skipping Israel because that country's government isn't fully formed after recent elections. (AP Photo/Jacquelyn Martin, File)

FILE - In this Feb. 14, 2013 file photo, Secretary of State John Kerry speaks at the State Department in Washington. Kerry will make his first overseas trip next week to Europe and the Middle East, but is skipping Israel because that country's government isn't fully formed after recent elections. (AP Photo/Jacquelyn Martin, File)

(AP) ? Secretary of State John Kerry is embarking on his first official overseas voyage, bringing new ideas to capitals in Europe and the Middle East on how to end nearly two years of brutal violence in Syria.

Kerry leaves Washington on Sunday on a grueling nine-nation, 10-day trip that will bring him to America's traditional western European allies of Britain, Germany, France and Italy along with Turkey, Egypt, Saudi Arabia, the United Arab Emirates and Qatar. In addition to Syria, he will focus on conflicts in Mali and Afghanistan and Iran's nuclear program.

Kerry has said he is eager to discuss new ways of convincing Syrian President Bashar Assad to step down and usher in a democratic transition in the country that has been wracked by increasing violence that has killed at least 70,000 people. He has not offered details of his ideas but officials say they revolve around increasing pressure on Assad and his inner circle.

Kerry begins his trip in London where he will see senior British officials on a range of issues, from Afghanistan to the status of the Falkland Islands, over which Britain is in a major dispute with Argentina.

He then travels to Germany to discuss trans-Atlantic issues with German youth in Berlin, where he spent time as a child as the son of an American diplomat posted to the divided Cold War city. He will also meet with Russian Foreign Minister Sergey Lavrov in the German capital.

In Paris, Kerry will discuss France's ongoing intervention in Mali. And in Rome, he'll attend a meeting with Syrian opposition leaders.

U.S. officials have said the trip will be primarily a "listening tour" when it comes to Syria and won't result in immediate shifts in U.S. policy that has until now stayed clear of military support for the rebels fighting Assad.

Despite the numerous Middle East stops. Kerry will not travel to Israel or the Palestinian territories. He will wait to visit them when he accompanies President Barack Obama there in March.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-24-Kerry/id-0495e16b4d954cdeb1537beb112bfb92

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Report: Chile's Pinochet wanted anti-vote violence

SANTIAGO, Chile (AP) ? Newly published U.S. documents indicate that Chilean dictator Augusto Pinochet sought to use military force to annul the referendum portrayed in the Oscar-nominated film "NO" that ended his brutal regime. The plan was rejected by his fellow generals, the papers say.

The formerly top-secret documents posted by the independent U.S. National Security Archive on Friday also show U.S. officials warning Chilean leaders against violence if Pinochet tried to use force to stay in power.

Pinochet "planned to do whatever was necessary to stay in power" just a day before the Oct. 5, 1988, referendum, according to a Defense Intelligence Agency document based on information from a Chilean air force officer.

"Pinochet reportedly told advisors: 'I'm not leaving, no matter what,'" the document said.

The documents also show that U.S. officials and agencies backed the anti-Pinochet campaign, even though the U.S. government had worked to undermine the socialist administration of President Salvador Allende that Pinochet overthrew in a 1973 coup and initially supported the new regime.

The papers portray Pinochet as furious after the vote results.

In a last attempt to retain power, the strongman who once compared himself to the greatest Roman emperors asked the members of the military junta to meet in his office in the presidential palace at 1:00 AM," says a report by the Defense Department titled: "Chile: plebiscite goes forward as Pinochet apparently loses."

A CIA source at the meeting describes Pinochet as being "nearly apoplectic" about the results.

"Pinochet was prepared on the night of 5 Oct to overthrow the results of the plebiscite," an informant said in a report by the State Department titled: "Chilean junta meeting the night of plebiscite."

Pinochet had a document prepared for other generals to sign and "spoke of using the extraordinary powers to have the armed forces seize the capital," says one of the reports by the Defense Department.

But even his closest allies said no. The air force commander, Gen. Fernando Matthei, "told Pinochet he would under no circumstances agree to such a thing ... Pinochet then turned to the others and made the same request and was turned down."

Losing all backing to overthrow the plebiscite, Pinochet accepted his defeat.

The lead-up to that decision is depicted in "NO," which is up for an Academy Award as best-foreign language film on Sunday. The Chilean film is based on the publicity campaign that helped oust Pinochet and return Chile to democracy.

The general ruled Chile from 1973 to 1990. He died under house arrest, without ever being tried, despite charges of illegal enrichment and human rights violations.

"We negotiated with him because we were never able to judge him and Pinochet died a free man and a millionaire," said Pablo Larrain, director of "NO," in an interview last month with The Associated Press.

The film's July premiere in Santiago unsettled many audiences because Chile remains deeply divided over Pinochet's regime.

He shut down Congress, outlawed political parties and forced thousands of dissidents into exile, while his police tortured and killed thousands more.

But loyalists saw him as a fatherly figure who oversaw Chile's growth into economic prosperity and kept it from becoming a failed socialist state.

"Given the entrenched and violent nature of Pinochet's dictatorship, the No Campaign's victory is all the more dramatic," said Peter Kornbluh, author of "The Pinochet File: A Declassified Dossier on Atrocity and Accountability."

Forty years after the coup, Kornbluh said, "It is not only important to remember how he took power, but was forced to relinquish it."

__

On the web: http://www.gwu.edu/~nsarchiv/NSAEBB/NSAEBB413/

__

Luis Andres Henao on Twitter: https://twitter.com/LuisAndresHenao

Source: http://news.yahoo.com/report-chiles-pinochet-wanted-anti-vote-violence-204935155.html

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Sunday, February 24, 2013

Earnhardt tops final practice for Daytona 500

DAYTONA BEACH, Fla. (AP) ? Quiet most of Speedweeks, Dale Earnhardt Jr. made a little noise Saturday.

Earnhardt topped the speed chart for the final practice session before Sunday's season-opening Daytona 500.

The 2004 Daytona 500 champion turned the fast lap by averaging 198.592 mph around the 2? -mile superspeedway. David Gilliland was second, followed by Clint Bowyer, Marcos Ambrose and Aric Almirola.

Pole-sitter Danica Patrick and Stewart-Haas Racing teammate Tony Stewart were among 10 drivers who skipped the 1? -hour final tuneup. Patrick is trying to become the first driver win the Daytona 500 from the pole since Dale Jarrett in 2000. Only nine drivers have accomplished the feat in 54 years.

Three-time Daytona 500 winner Jeff Gordon, 2010 Daytona 500 champ Jamie McMurray, Casey Mears, Terry Labonte and Joe Nemechek also sat out the session. So did Joe Gibbs Racing teammates Kyle Busch, Denny Hamlin and Matt Kenseth.

"We don't have any plans to go out," Gordon said. "We feel like this entire week we have been able to learn everything we need to get prepared for the race tomorrow. ... We've got a great race car. We are excited. We've got a great opportunity here."

Before Saturday, Earnhardt had done little during Speedweeks. He finished eighth in the Sprint Unlimited and ninth in his qualifying race. He will start 19th in the "Great American Race," his lowest opening spot in 14 years at NASCAR's premier event.

His speed in the final practice had to boost the team's confidence.

Almirola, however, posted the best 10-lap average. He averaged 196.195 mph over 10 laps on new tires. Earnhardt was sixth on that chart.

"We are excited about this weekend and feel like we have a good car and got it driving good in that last practice session," Almirola said.

The final session involved little bump-drafting and even less side-by-side action ? no doubt because teams were leery of wrecking race cars about 24 hours before the Daytona 500.

Defending Sprint Cup Series champion Brad Keselowski provided the most action when he hit a bird.

"I killed a Tweetie bird," said Keselowski, one of auto racing's top Tweeters.

Keselowski was 17th in the final practice.

"This is our 500 engine, so trying to get an idea of how it's going to perform," he said. "My car is really good. Definitely faster than what it was, so that's good, right? I'm definitely optimistic."

Of the teams that didn't practice, most of them valued keeping their car intact over incremental gains that could be found so late in Speedweeks.

Patrick, Stewart, Gordon and the Gibbs cars have been some of the fastest all week.

Source: http://news.yahoo.com/earnhardt-tops-final-practice-daytona-500-175130887--spt.html

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Live from Mobile World Congress with Huawei

Huawei MWC event

We're live from Barcelona, Spain with Huawei, which is holding its big press conference today ahead of MWC. Possible Android developments include the Ascend P2, a quad-core successor to last year's Ascend P1. The action starts at 3pm Barcelona time (9am ET), so stick around for all the day's announcements!

You'll find our liveblog after the break.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/A96jeDvOE9E/story01.htm

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Snowstorm dies down, Midwest travel woes tick up

MINNEAPOLIS (AP) ? Gusty winds and iced-over roadways made for treacherous Midwest travel Friday as a major winter storm headed east over the Great Lakes.

Two deaths have been linked to the storm, including one in a fatal traffic accident in Minnesota. Accidents and slide-offs were widespread across the affected states. Commuters faced strong winds of Lake Michigan in eastern Wisconsin. While Chicago's large fleet of snowplows salted and cleared the city's streets of 3 inches of snow, commuters slogged through slush to get to their offices.

About 270 flights in and out of Chicago's two airports were canceled Friday morning. Arrival delays of up to 90 minutes were reported at O'Hare airport. The Kansas City and St. Louis, Mo., airports both reopened Friday morning but had numerous cancellations and delays.

The snow began falling in Detroit just in time for the morning rush, turning streets and freeways into a mess.

Head bowed and arms crossed, 45-year-old Patrice Denham pushed forward into Detroit's swirling snow. She had just walked several blocks to her townhouse complex's leasing office for a new mailbox key and was heading back home.

"You live in the city of Detroit and you do what you have to do," Denham said referring to the rough winter weather that regularly affects the city. "If it's going to be cold, it's going to be cold. But this has been only an average winter."

Where the storm struck hardest Wednesday and Thursday, impressive snow totals rolled in ? 17 inches in Hays, Kan.; 13 inches in northern Oklahoma; 13 ? inches in northeast Missouri and south-central Nebraska; and 12 inches in parts of Kansas City, Mo.

As it moved farther north and east overnight and into Friday, the system lost strength. Illinois' totals ranged from 7.5 inches in the west-central town of Rushville to a mix of sleet and freezing rain in the St. Louis, Mo., suburbs. Dodge County in southeastern Minnesota received 8 inches by Friday morning, and Trempealeau County of western Wisconsin had 7 inches.

Students across a large swath of Kansas spent a second day at home as crews continue to excavate residential neighborhoods. Schools also were closed Friday in parts of Missouri, Michigan, Wisconsin and Minnesota.

The Kansas Legislature was back in session Friday after canceling its meetings Thursday, but lawmakers' schedule was light.

Travel continued to be the major issue Friday.

A United plane slid off a slick runway at the Cleveland airport onto a grassy area Friday morning. No injuries were reported.

The Minnesota State Patrol blamed the snow for over 200 accidents during the Friday morning commute. One driver was killed when a vehicle lost control, slid into oncoming traffic and was broadsided on a highway in the St. Paul suburb of Eagan.

A death in western Iowa was also linked to the storm when a woman was run over Thursday by her car, which had gotten stuck on her steep, slippery driveway.

Also in Iowa, a bus carrying members of a college softball team was involved in a multi-vehicle crash Friday morning. It closed part of Interstate 80 east of Des Moines, and no serious injuries were reported.

In some locations, the storm didn't live up to the hype. At the Pilot Flying J station near Interstate 29 in southwest Iowa, shift manager Kelly Malone said Friday his company had taken precautions by reserving seven rooms for employees at the nearby Super 8 Motel.

"We were prepared for the worst, but it didn't happen that bad," he said. Iowa's snow totals topped out at 9.7 inches near Sioux City.

"To me it was just an average storm, but I'm a person who drives through anything," he said.

___

Associated Press reporters Corey Williams in Detroit; Jim Suhr in St. Louis, Mo.; Heather Hollingsworth in Kansas City, Mo.; Gretchen Ehlke in Milwaukee; Nelson Lampe in Omaha, Neb.; and Tom Sheeran in Cleveland contributed to this story.

Source: http://news.yahoo.com/snowstorm-dies-down-midwest-travel-woes-tick-162819610.html

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Megan Fox Joins New Ninja Turtles

That splat between Megan Fox and Michael Bay? It's water under the bridge. The two will re-unite for Ninja Turtles, The Hollywood Reporter has learned.

Bay made it know that the two overcame their differences when he posted a simple message announcing Fox's casting in the forthcoming Teenage Mutant Ninja Turtles reboot: "TMNT: we are bringing Megan Fox back into the family!"

While he didn't say which role Fox will be playing, THR believes she'll be playing April O'Neil, a news reporter who's on the side of the Turtles. Fox is the only actor officially attached to the movie thus far.

In this live-action reboot, the Turtles are extraterrestrial in origin, but other than that, they'll be the same old Turtles we know and love. Unlike previous live-action movies, the Turtles in the reboot will be motion-captured CGI creations.

The movie is in the casting stages and will probably go before the cameras this spring or summer for a May 16, 2014 release. Battle Los Angeles' Jonathan Liebesman is attached to direct, with Bay producing.

As for why Fox wants to work with Bay again, here's what she said back in 2009:

"You get addicted to those big action movies You get addicted to the Bay-hem. You step away from it, and you're relieved and you're relaxed and you do something that's quieter and you feel like you're really working on it and you're fleshing out and figuring things out. But then you sort of miss that abuse."


Is this what the Turtles will look like?

Source: http://www.rottentomatoes.com/m/1926898/news/1926898/

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Saturday, February 23, 2013

Dean Cain on Mindy McCready: What a WASTE!

Source: http://www.thehollywoodgossip.com/2013/02/dean-cain-on-mindy-mccready-what-a-waste/

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Nearly a decade since the Iraq War started: Share your story

On March 19, 2003, the U.S. began military operations in Iraq.

For nearly nine years, America?s profile in the region shifted between invader, liberator, occupier, nation-builder, caretaker and more.

When the U.S. officially ended the war on Dec. 15, 2011, and withdrew the last of its combat troops, the nation had seen 4,409 Americans killed in Iraq and 31,926 more wounded in action. (The number of Iraqi deaths are estimated at 122,000 through today.) At times during the 2007 surge, the number of U.S. boots on the ground grew to nearly 150,000.

Behind those numbers, of course, lie personal stories of service members and their families. As we approach the exact date of the anniversary, Yahoo News is inviting you to share your stories. We?re publishing first-person stories written not only by Americans who served in Iraq in the past 10 years, but also family members of troops, to hear how they?ve changed, too.

If you?re interested in sharing your story, please go to Yahoo! Contributor Network for more details. If you have questions, please email us at contributor-news@yahoo-inc.com.

Stories that we accept will be published under your byline on Yahoo News. The deadline for submissions is March 7.

We appreciate your participation and look forward to receiving your first-person account.

Source: http://news.yahoo.com/blogs/lookout/10-years-since-iraq-war-started-share-story-225440850.html

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Friday, February 22, 2013

3 political sisters in Pa. convicted of corruption

FILE - In this April 7, 2010 file photo, former Pennsylvania state Sen. Jane Orie, left, her sisters Janine Orie, right, and Pennsylvania Supreme Court Justice Joan Orie Melvin, center right, listen as their brother Jack Orie, center, reads a statement to the press outside a magistrate's office in Pittsburgh. With the conviction of Melvin and Janine Orie on Thursday, Feb. 21, 2013, and Jane Orie's 2012 conviction, all three sisters were found guilty in campaign related in campaign corruption crimes. (AP Photo/Keith Srakocic, File)

FILE - In this April 7, 2010 file photo, former Pennsylvania state Sen. Jane Orie, left, her sisters Janine Orie, right, and Pennsylvania Supreme Court Justice Joan Orie Melvin, center right, listen as their brother Jack Orie, center, reads a statement to the press outside a magistrate's office in Pittsburgh. With the conviction of Melvin and Janine Orie on Thursday, Feb. 21, 2013, and Jane Orie's 2012 conviction, all three sisters were found guilty in campaign related in campaign corruption crimes. (AP Photo/Keith Srakocic, File)

FILE - In this Feb. 29, 2012 file photo, former Pennsylvania state Sen. Jane Orie, R-Allegheny, walks to the Allegheny County Courthouse in Pittsburgh. Orie was found guilty and is serving 2? to 10 years in prison for misusing her state-funded staffers on her own campaigns. With the conviction of her sisters, Pennsylvania Supreme Court Justice Joan Orie Melvin, and Janine Orie on Thursday, Feb. 21, 2013, all three sisters were found guilty in campaign corruption crimes. (AP Photo/Gene J. Puskar, File)

FILE--In this April 7, 2010 file photo, Janine Orie leaves a magistrate's office in Pittsburgh after turning herself in. With her conviction along with sister Pennsylvania Supreme Court Justice Joan Orie Melvin, on Thursday, Feb. 21, 2013, and the 2012 conviction of third sister, former state senator Jane Orie, all three sisters were found guilty in campaign corruption crimes. (AP Photo/Keith Srakocic, FILE)

FILE - In this May 18, 2012 file photo Pennsylvania Supreme Court Justice Joan Orie Melvin, speaks to reporters outside Pittsburgh Municipal Court in Pittsburgh. With her conviction along with sister Janine Orie on Thursday, Feb. 21, 2013, and the 2012 conviction of third sister, former state senator Jane Orie, all three sisters were found guilty in campaign corruption crimes. (AP Photo/Keith Srakocic, File)

State Supreme Court Justice Joan Orie Melvin leaves the Allegheny County Courthouse Thursday, Feb. 21 2013 in Pittsburgh. Justice Joan Orie Melvin was convicted Thursday of corrupting the election process in her campaigns to win a seat on the bench, making her just the second known Supreme Court justice to be convicted in nearly three centuries and triggering renewed calls to change the system of electing state judges. (AP Photo/Tribune Review, Philip G. Pavely) PITTSBURGH OUT

(AP) ? The story has more irony than a Greek tragedy. Three sisters from a devoutly Catholic family have seen their personal and political careers ruined by a scandal that began with, of all things, a letter to some nuns.

Thursday's conviction of suspended state Supreme Court Justice Joan Orie Melvin along with her aide and sister, Janine Orie, on campaign corruption charges mean they might join a third sister ? former state Sen. Jane Orie ? in state prison. No sentencing date has been set.

The former senator was sentenced last year to 2? to 10 years for using her state-paid staff to run her campaigns, though she was acquitted of having them campaign for Melvin, then a lower appellate court judge, who was running for the Supreme Court in 2003 and 2009. Joan Orie Melvin and Janine Orie were convicted in a spinoff investigation and found guilty of similarly misusing Melvin's former staff and the senator's.

Even before the convictions, their careers ? and the family from which they sprang ? were extraordinary.

Dr. John Orie, now 90, and his late wife, Jean, raised nine children including five attorneys, Joan and Jane among them; two cardiologists; a teacher; and a human resources manager, Janine, who worked for her sister Joan Orie Melvin in the lower Superior Court before moving up with her to the Supreme Court.

"It's all pretty unbelievable," said John Burkoff, a university of Pittsburgh law professor who has closely followed the cases. "Whatever you thought about the Orie sisters, whether you liked or didn't like them, you have to look at all of this as tragic."

Jim Roddey is a prominent businessman who heads the Republican Party in Allegheny County, where Republicans are outnumbered more than 2 to 1 by Democrats and where Pittsburgh, the county seat, hasn't elected a GOP mayor since the Great Depression.

Before 2010, when Republican Tom Corbett was elected governor, Jane Orie was the state Senate majority whip ? the highest-ranking elected Republican politician not just in Pennsylvania, but also of several states in the Northeast, Roddey said. And Melvin, elected in November 2009, was one of seven members of the state's highest court.

And now? Jane Orie resigned her Senate seat in May, and Melvin's status on the state's highest court figures to change, one way or another.

State lawmakers have already asked her to resign or face articles of impeachment. If those are approved by the state House, Melvin would be tried by the Senate, which could remove her from office if she hasn't already been removed by the state's Court of Judicial Discipline.

Now that she has been convicted, Melvin has 30 days to respond to charges of misconduct filed with that court by the state's Judicial Conduct Board. If it is determined Melvin has violated professional conduct rules or the state Constitution, or brought disrepute to the judiciary, the court can remove her from office.

Melvin's criminal defense attorneys and her disciplinary court attorney didn't return calls Friday.

The Ories have argued the prosecution is the result of a political vendetta by Allegheny County District Attorney Stephen Zappala Jr., a Democrat, who has repeatedly denied ulterior motives.

When the investigation first became public in late 2009, the sisters claimed they were being targeted because Zappala's family has interests in legalized gambling, which the Ories opposed expanding in Pennsylvania.

The allegations grew uglier, when Melvin ? after it was known Sen. Orie was being investigated but before the justice was charged ? called for an audit of two child care centers that paid kickbacks to two judges in northeastern Pennsylvania's Luzerne County who sent troubled youths to the facilities. The facilities were co-owned by Gregory Zappala, the prosecutor's brother, who was never charged in the scheme and has repeatedly denied wrongdoing.

To this day, some Orie supporters still believe those politics ? not justice ? drove the prosecution.

Roddey acknowledges the sisters' success in a politically hostile environment has something to do with that chatter.

"That's part of it," Roddey said. "But the other half of the equation is that her prosecutor was Stephen Zappala, and Joan's biggest public battle was she chastised the Supreme Court for what happened in Luzerne County."

Whatever the motivations, two juries have now found enough evidence to bring the overachieving siblings from triumph to tragedy despite a raft of supporters ? Sen. Orie spent $420 on a chartered bus to bring 50 character witnesses to her trial ? and, even, efforts to seek divine intervention.

During the investigation, which centered on the sisters' emails, prosecutors stumbled onto messages Sen. Orie and Melvin sent to the "angel lady," a Philadelphia psychic who read her client's written questions aloud before claiming to receive a whispered answer from an angel.

The senator and justice sought assurances from the $85-an-hour medium that Zappala's investigation wouldn't result in criminal charges.

But rather than being touched by an angel, the sisters were undone by some nuns.

That happened in late October 2009 ? days before Melvin won her Supreme Court seat ? when a Senate intern complained to Zappala that Sen. Orie's staff was doing campaign work for Melvin.

The complaint centered on a letter Sen. Orie wrote on Melvin's campaign stationery asking Pittsburgh-area nuns to vote for Melvin.

When Orie and Melvin learned of the whistleblowing intern, the senator had a staffer prepare another letter ? a "cover-up" letter, according to prosecutors. This time, Sen. Orie ? on her own stationery ? spoke about civic events of interest to nuns but didn't mention Melvin.

Prosecutors contend the letter was created to make it appear the intern was simply mistaken about what she saw and was never mailed. Eventually, Sen. Orie's and Melvin's staffs told a grand jury about other illegal campaign work done in Orie's Senate offices and Melvin's chambers.

"Frankly, it's a smart group of people. How could they put themselves in this kind of situation?" Burkoff said. "This is the kind of thing we'll be puzzling about for years."

___

Jackson reported from Harrisburg, Pa.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-22-Pennsylvania%20Judge-Corruption/id-7028e3c7510942b19cc71cd21d95d5c6

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Fruit flies force their young to drink alcohol for their own good

Feb. 22, 2013 ? The fruit fly study adds to the evidence "that using toxins in the environment to medicate offspring may be common across the animal kingdom," says biologist Todd Schlenke.

When fruit flies sense parasitic wasps in their environment, they lay their eggs in an alcohol-soaked environment, essentially forcing their larvae to consume booze as a drug to combat the deadly wasps.

The discovery by biologists at Emory University is being published in the journal Science on February 22.

"The adult flies actually anticipate an infection risk to their children, and then they medicate them by depositing them in alcohol," says Todd Schlenke, the evolutionary geneticist whose lab did the research. "We found that this medicating behavior was shared by diverse fly species, adding to the evidence that using toxins in the environment to medicate offspring may be common across the animal kingdom."

Adult fruit flies detect the wasps by sight, and appear to have much better vision than previously realized, he adds. "Our data indicate that the flies can visually distinguish the relatively small morphological differences between male and female wasps, and between different species of wasps."

The experiments were led by Balint Zacsoh, who recently graduated from Emory with a degree in biology and still works in the Schlenke lab. The team also included Emory graduate student Zachary Lynch and postdoc Nathan Mortimer.

The larvae of the common fruit fly, Drosophila melanogaster, eat the rot, or fungi and bacteria, that grows on overripe, fermenting fruit. They have evolved a certain amount of resistance to the toxic effects of the alcohol levels in their natural habitat, which can range up to 15 percent.

Tiny, endoparasitoid wasps are major killers of fruit flies. The wasps inject their eggs inside the fruit fly larvae, along with venom that aims to suppress their hosts' cellular immune response. If the flies fail to kill the wasp egg, a wasp larva hatches inside the fruit fly larva and begins to eat its host from the inside out.

Last year, the Schlenke lab published a study showing how fruit fly larvae infected with wasps prefer to eat food high in alcohol. This behavior greatly improves the survival rate of the fruit flies because they have evolved high tolerance of the toxic effects of the alcohol, but the wasps have not.

"The fruit fly larvae raise their blood alcohol levels, so that the wasps living in their blood will suffer," Schlenke says. "When you think of an immune system, you usually think of blood cells and immune proteins, but behavior can also be a big part of an organism's immune defense."

For the latest study, the researchers asked whether the fruit fly parents could sense when their children were at risk for infection, and whether they then sought out alcohol to prophylactically medicate them.

Adult female fruit flies were released in one mesh cage with parasitic wasps and another mesh cage with no wasps. Both cages had two petri dishes containing yeast, the nourishment for lab-raised fruit flies and their larvae. The yeast in one of the petri dishes was mixed with 6 percent alcohol, while the yeast in the other dish was alcohol free. After 24 hours, the petri dishes were removed and the researchers counted the eggs that the fruit flies had laid.

The results were dramatic. In the mesh cage with parasitic wasps, 90 percent of the eggs laid were in the dish containing alcohol. In the cage with no wasps, only 40 percent of the eggs were in the alcohol dish.

"The fruit flies clearly change their reproductive behavior when the wasps are present," Schlenke says. "The alcohol is slightly toxic to the fruit flies as well, but the wasps are a bigger danger than the alcohol."

The fly strains used in the experiments have been bred in the lab for decades. "The flies that we work with have not seen wasps in their lives before, and neither have their ancestors going back hundreds of generations," Schlenke says. "And yet, the flies still recognize these wasps as a danger when they are put in a cage with them."

Further experiments showed that the flies are extremely discerning about differences in the wasps. They preferred to lay their eggs in alcohol when female wasps were present, but not if only male wasps were in the cage.

Theorizing that the flies were reacting to pheromones, the researchers conducted experiments using two groups of mutated fruit flies. One group lacked the ability to smell, and another group lacked sight. The flies unable to smell, however, still preferred to lay their eggs in alcohol when female wasps were present. The blind flies did not make the distinction, choosing the non-alcohol food for their offspring, even in the presence of female wasps.

"This result was a surprise to me," Schlenke says. "I thought the flies were probably using olfaction to sense the female wasps. The small, compound eyes of flies are believed to be more geared to detecting motion than high-resolution images."

The only obvious visual differences between the female and male wasps, he adds, is that the males have longer antennae, slightly smaller bodies, and lack an ovipositor.

Further experimentation showed that the fruit flies can distinguish different species of wasps, and will only choose the alcohol food in response to wasp species that infect larvae, not fly pupae. "Fly larvae usually leave the food before they pupate," Schlenke explains, "so there is likely little benefit to laying eggs at alcoholic sites when pupal parasites are present."

The researchers also connected the exposure to female parasitic wasps to changes in a fruit fly neuropeptide.

Stress, and the resulting reduced level of neuropeptide F, or NPF, has previously been associated with alcohol-seeking behavior in fruit flies. Similarly, levels of a homologous neuropeptide in humans, NPY, is associated with alcoholism.

"We found that when a fruit fly is exposed to female parasitic wasps, this exposure reduces the level of NPF in the fly brain, causing the fly to seek out alcoholic sites for oviposition," Schlenke says. "Furthermore, the alcohol-seeking behavior appears to remain for the duration of the fly's life, even when the parasitic wasps are no longer present, an example of long-term memory."

Finally, Drosophila melanogaster is not unique in using this offspring medication behavior. "We tested a number of fly species," Schlenke says, "and found that each fly species that uses rotting fruit for food mounts this immune behavior against parasitic wasps. Medication may be far more common in nature than we previously thought."

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Story Source:

The above story is reprinted from materials provided by Emory Health Sciences. The original article was written by Carol Clark.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. B. Z. Kacsoh, Z. R. Lynch, N. T. Mortimer, T. A. Schlenke. Fruit Flies Medicate Offspring After Seeing Parasites. Science, 2013; 339 (6122): 947 DOI: 10.1126/science.1229625
  2. Neil?F. Milan, Balint?Z. Kacsoh, Todd?A. Schlenke. Alcohol Consumption as Self-Medication against Blood-Borne Parasites in the Fruit Fly. Current Biology, 2012; 22 (6): 488 DOI: 10.1016/j.cub.2012.01.045

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/553YyOM3vUk/130222102958.htm

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Thursday, February 21, 2013

1.9nJ/b Ultra-low power 2.4GHz multi-standard radio compliant to Bluetooth? Low Energy and ZigBee?

Home > Press > 1.9nJ/b Ultra-low power 2.4GHz multi-standard radio compliant to Bluetooth? Low Energy and ZigBee?

Abstract:
International Solid State Circuits Conference) - February 22, 2013 - Imec and Holst Centre presented at ISSCC an ultra-low power multi-standard 2.3/2.4GHz short range radio. The 1.9nJ/b radio is compliant with three wireless standards: Bluetooth ? Low Energy (BLE), ZigBee (IEEE802.15.4) and Medical Body Area Networks (MBAN, IEEE802.15.6). A proprietary 2Mbps mode is also implemented to support data-streaming applications like hearing aids. The radio is 3-5 times more power-efficient than current Bluetooth Low Energy solutions.

San Francisco, CA | Posted on February 21st, 2013

"From health care to smart buildings, adding sensors to our environment will support and enhance our day-to-day life. Applications are numerous and restricted mainly by our imagination? and by the power consumption of the mostly battery-operated sensor devices," said Harmke De Groot, Program Director Ultra Low Power Circuits at Holst Centre/imec. "The radio often consumes between 50-85% of the overall power consumption of a sensor system. And for autonomous devices, with only a small battery and thus limited battery energy, the power consumption of commercially available short-range radios is rather high (>15mW DC power)."

Imec and Holst Centre developed an ultra-low power multi-standard radio with state-of-the-art sensitivity. The radio significantly reduces the power consumption of the overall sensor system compared to off-the-shelf radios. As a result, the autonomy of the device is increased, or more functionality can be added to the sensor device, increasing its quality, functionality and/or performance. Or, the battery size can be reduced, resulting in a smaller device, which in case of wearable systems, adds to the comfort of the user.

The 2.4GHz radio is implemented in 90nm CMOS technology. Using a highly energy efficient architecture and optimizing the most power hungry building blocks, resulted in a 2.4GHz radio with world-class energy efficiency while supporting the most common standards for mobile sensor networks (BLE?, ZigBee ? and IEEE802.15.6). Imec and Holst Centre's energy-efficient radio architecture has a suitable LO frequency plan and several efficiency-enhancement techniques for the critical RF circuits. As a result, the radio achieves a DC power of only 3.8mW at 1.2V supply for the receiver and 4.6mW for the transmitter. This is 3 to 5 times more power-efficient than the current state-of-the-art Bluetooth Low Energy solutions. The measured RX noise figure is 6dB, resulting in an excellent sensitivity in each standard (-100/-98/-96.5dBm for Zigbee/BLE/MBAN). With a measured IIP3 of -19dBm at the maximum front-end gain, the RX can accommodate the BLE intermodulation test level to -40dBm (spec. >-50dBm).

These results were presented at the 2013 IEEE International Solid-State Circuits Conference (ISSCC) in San Francisco (February 17-21, 2013).

####

About IMEC
Imec performs world-leading research in nanoelectronics. Imec leverages its scientific knowledge with the innovative power of its global partnerships in ICT, healthcare and energy. Imec delivers industry-relevant technology solutions. In a unique high-tech environment, its international top talent is committed to providing the building blocks for a better life in a sustainable society. Imec is headquartered in Leuven, Belgium, and has offices in Belgium, the Netherlands, Taiwan, US, China, India and Japan. Its staff of close to 2,000 people includes more than 600 industrial residents and guest researchers. In 2011, imec's revenue (P&L) was about 300 million euro. Further information on imec can be found at www.imec.be.

Imec is a registered trademark for the activities of IMEC International (a legal entity set up under Belgian law as a "stichting van openbaar nut?), imec Belgium (IMEC vzw supported by the Flemish Government), imec the Netherlands (Stichting IMEC Nederland, part of Holst Centre which is supported by the Dutch Government), imec Taiwan (IMEC Taiwan Co.) and imec China (IMEC Microelectronics (Shangai) Co. Ltd.) and imec India (Imec India Private Limited).

About Holst Centre

Holst Centre is an independent open-innovation R&D centre that develops generic technologies for Wireless Autonomous Transducer Solutions and for Systems-in-Foil. A key feature of Holst Centre is its partnership model with industry and academia around shared roadmaps and programs. It is this kind of cross-fertilization that enables Holst Centre to tune its scientific strategy to industrial needs.

Holst Centre was set up in 2005 by imec (Flanders, Belgium) and TNO (The Netherlands) with support from the Dutch Ministry of Economic Affairs and the Government of Flanders. It is named after Gilles Holst, a Dutch pioneer in Research and Development and first director of Philips Research. Located on High Tech Campus Eindhoven, Holst Centre benefits from the state-of-the-art on-site facilities. Holst Centre has over 180 employees from around 28 nationalities and a commitment from more than 45 industrial partners.

Visit us at www.holstcentre.com

For more information, please click here

Contacts:
Imec :
Hanne Degans
External Communications Officer
T: +32 16 28 17 69
Mobile: +32 486 06 51 75

Holst Centre :
Koen Snoeckx
Communication Manager
T: +31 40 40 20 561
M : +31 612 71 98 43

Olga Walsh
Business Technology
[ f o r m u l a ]
Formula PR, Inc.
1215 Cushman Avenue
San Diego, CA 92110
Office 619-234-0345 |

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